Author: DONG, Chun-Honga CHANG, Jun-Biao ,a,b WANG, Qiangb QI, Xiu-Xiangc YU, Xue-Junc ( a Department of Chemistry, University of Science and Technology of China, Hefei 230026) ( b Research Center of Henan Academy, Zhengzhou 450002) ( c Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000)
Abstract: An efficient synthesis of N4-cyclopropylamino-5-fluoro-β-L-uridine was developed from L-arabinose. L-Arabinose was converted to compound L-ribopyranose (6), which was used for the synthesis of the key intermediate 2,3,5-tri-O-benzoyl-1-O-acetyl-β-L-ribofuranose (9). The compound 9 was subjected to condensation with silylated 5-fluoro-uracil to give the resulting protected compound 5-fluoro-3-(2′,3′,5′-tri-O-benzoyl-β-L-ribofuranosyl)-uracel(10). Compound 10 was deprotected to give 5-fluoro-β-L-u... 
Key words: L-arabinose； synthesis； L-nucleoside；